2,076 research outputs found

    Reversal of methotrexate-induced cytotoxicity by 5-methyl tetrahydrofolate : implications for chemotherapy

    Get PDF

    A Description Model for Regeneration through Urban Tourism in Rural Towns with Underused Historic Real Estate

    Get PDF
    Abstract This paper deals with the construction of a description model that will be helpful for an actual decision aiding situation posed by the urban planner for tourism development of rural towns in Sicilian hinterland areas. The decision problem concerns the town of Cianciana, which in recent years has become the protagonist of a particular international tourism phenomenon. We propose a multi-criteria evaluation framework for the rehabilitation of the historic town centre through tourism development. The description problem model that is presented here is focused on aiding decision makers to identify the best usage strategy of under-utilized historic real estate for tourist accommodation. Although the evaluation framework has been inspired by the particular case of Cianciana, it would fit well for evaluations undertaken in analogue circumstances

    TASTE IV. Refining ephemeris and orbital parameters for HAT-P-20b and WASP-1b

    Full text link
    We present four new light curves of transiting exoplanets WASP-1b and HAT-P-20b, observed within the TASTE (The Asiago Search for Transit timing variations of Exoplanets) project. We re-analyzed light curves from the literature in a homogeneous way, calculating a refined ephemeris and orbital-physical parameters for both objects. WASP-1b does not show any significant Transit Timing Variation signal at the 120 s-level. As for HAT-P-20b, we detected a deviation from our re-estimated linear ephemeris that could be ascribed to the presence of a perturber or, more probably, to a previously unnoticed high level of stellar activity. The rotational period of HAT-P-20 A we obtained from archival data (P_rot ~ 14.5 days), combined with its optical variability and strong emission of CaII H&K lines, is consistent with a young stellar age (< 1 Gyr) and support the hypothesis that stellar activity may be responsible of the measured deviations of the transit times.Comment: 7 pages, 4 figures, 3 tables, accepted to Astronomische Nachrichte

    Variable stars in one open cluster within the Kepler/K2-Campaign-5 field: M 67 (NGC 2682)

    Full text link
    In this paper we continue the release of high-level data products from the multiyear photometric survey collected at the 67/92 cm Schmidt Telescope in Asiago. The primary goal of the survey is to discover and to characterise variable objects and exoplanetary transits in four fields containing five nearby open clusters spanning a broad range of ages. This second paper releases a photometric catalogue, in five photometric bands, of the Solar-age, Solar-metallicity open cluster M 67 (NGC 2682). Proper motions are derived comparing the positions observed in 2013 at the Asiago's Schmidt Telescope with those extracted from [email protected] MPG/ESO images in 2000. We also analyse the variable sources within M 67. We detected 68 variables, 43 of which are new detection. Variable periods and proper-motion memberships of a large majority of sources in our catalogue are improved with respect to previous releases. The entire catalogue will be available in electronic format. Besides the general interest on an improved catalogue, this work will be particularly useful because of: (1) the imminent release of Kepler/K2 Campaign-5 data of this cluster, for which our catalogue will provide an excellent, high spatial resolution input list, and (2) characterisation of the M 67 stars which are targets of intense HARPS and HARPS-N radial-velocity surveys for planet search.Comment: 8 pages, 6 figures (2 at low resolution), 2 tables. Accepted for publication in MNRAS on October 17, 2015. Electronic materials available at the url http://groups.dfa.unipd.it/ESPG/M67.html , and later on the Journal and at the CD

    Study of the Quench Propagation and of the Protection System of the COS-theta NED Dipole Prototype

    Get PDF
    In this report we present our studies of the propagation of the quench in the NED dipole prototype, to derive a preliminary configuration of the protection system of the magnet (quench protection heaters, dump resistors, etc.). The simulations have been performed by using the code QLASA [1]. In this code, the geometry of the magnet is simplified to a series of solenoidal concentric magnets and the evolution of the quench is calculated with the Wilson's approach [2]. An analogous study has been performed with the CERN code QUABER [3],[4], and the results are discussed in section 3

    TASTE. III. A homogeneous study of transit time variations in WASP-3b

    Full text link
    The TASTE project is searching for low-mass planets with the Transit Timing Variation (TTV) technique, by gathering high-precision, short-cadence light curves for a selected sample of transiting exoplanets. It has been claimed that the "hot Jupiter" WASP-3b could be perturbed by a second planet. Presenting eleven new light curves (secured at the IAC80 and UDEM telescopes) and re-analyzing thirty-eight archival light curves in a homogeneous way, we show that new data do not confirm the previously claimed TTV signal. However, we bring evidence that measurements are not consistent with a constant orbital period, though no significant periodicity can be detected. Additional dynamical modeling and follow-up observations are planned to constrain the properties of the perturber or to put upper limits to it. We provide a refined ephemeris for WASP-3b and improved orbital/physical parameters. A contact eclipsing binary, serendipitously discovered among field stars, is reported here for the first time.Comment: 10 pages, 6 figures, 4 tables; accepted for publication in A&

    Topology-Induced Critical Current Enhancement in Josephson Networks

    Full text link
    We investigate the properties of Josephson junction networks with inhomogeneous architecture. The networks are shaped as "quare comb" planar lattices on which Josephson junctions link superconducting islands arranged in the plane to generate the pertinent topology. Compared to the behavior of reference linear arrays, the temperature dependencies of the Josephson currents of the branches of the network exhibit relevant differences. The observed phenomena evidence new and surprising behavior of superconducting Josephson arrays as well as remarkable similarities with bosonic junction arrays.Comment: improved figures (added magnetic pattern and single junction switching) some changes in the text and in the titl

    The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders

    Get PDF
    A wind of change characterizes epilepsy research efforts. The traditional approach, based on a neurocentric view of seizure generation, promoted understanding of the neuronal mechanisms of seizures; this resulted in the development of potent anti-epileptic drugs (AEDs). The fact that a significant number of individuals with epilepsy still fail to respond to available AEDs restates the need for an alternative approach. Blood-brain barrier (BBB) dysfunction is an important etiological player in seizure disorders, and combination therapies utilizing an AED in conjunction with a “cerebrovascular” drug could be used to control seizures more effectively than AED therapy alone. The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more “holistic” approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy
    corecore